Request for Proposals: 2022 Research Grant Program

CLOVES Syndrome (“CLOVES”) is a rare disorder. CLOVES syndrome is rare and very variable; ranging from mild to severe. The common features in most patients allow for proper diagnosis and distinction from other syndromes. The most consistent features of CLOVES are:  fatty truncal mass, vascular anomalies, aggressive overgrowth, abnormal extremities, scoliosis and skin abnormalities.  CLOVES is caused by a somatic genetic mutation in a gene called PIK3CA that increases the activity of the gene. CLOVES belongs to a category of diseases known as PIK3CA-overgrowth spectrum or PROS.  There are currently no approved therapies or clinical trials in place for the treatment for CLOVES.  CLOVES Syndrome Community supports, educates, empowers and improves the lives of those affected by CLOVES.

Eligibility Criteria 

This grant program is open to research investigators affiliated with an academic institution, hospital system, non-profit institution, or other accredited research institutions based in the United States (U.S.) or internationally. Eligible applicants include post-doctoral fellows, clinical fellows, researchers, physicians, or other associated research professionals with faculty appointments or research positions. 

Research Priorities: To obtain a better understanding of PIK3CA mutations in people with CLOVES and PIK3CA related conditions.  To accelerate treatment options and to improve quality of life in our rare disease population, consistent with CLOVES Syndrome Community’s mission. 


Applicants may request up to $50,000 in direct costs to support the Research Priorities, to be expended within 12 months of the receipt of funds. Indirect costs are not supported. 

2022 Grant Program Dates

Program opensJanuary 15, 2022
Full applications dueMarch 15, 2022
Award announcementsMay 20, 2022
Anticipated project start dateSummer 2022

Application Review Process 

Applications will be reviewed by the CLOVES Syndrome Community Scientific Medical and Advisory Board and the Board of Directors. The grant selection process is unbiased and independent; awards are based solely on scientific merit and expected contribution to the body of knowledge about CLOVES. Advisors and board members with a conflict of interest will not participate in voting for those specific applications.

Questions?  Email [email protected]